690 Galectin-12 regulates sebaceous gland function
نویسندگان
چکیده
منابع مشابه
Diffuse sebaceous-gland hyperplasia.
Diffuse sebaceous-gland hyperplasia is a rarevariant of sebaceous-gland hyperplasia that isdistinct from the well-known circumscribed type.The term presenile sebaceous hyperplasia has beenutilized to describe this entity that is distinguishedby specific features, which include confluence oflesions that results in the formation of large plaqueson the face, the sparing of periorificial regions, a...
متن کاملSebaceous gland lipids.
The principal activity of mature sebaceous glands is producing and secreting sebum, which is a complex mixture of lipids. Sebum composition is different among species and this difference is probably due to the function that sebum has to absolve. In human sebum there are unique lipids, such as squalene and wax esters not found anywhere else in the body nor among the epidermal surface lipids. Mor...
متن کاملGalectin-12
Galectin-12, a member of the galectin family of animal lectins, is preferentially expressed in adipocytes. We recently reported that this galectin is localized on lipid droplets, specialized organelles for fat storage. Galectin-12 regulates lipid degradation (lipolysis) by modulating lipolytic protein kinase A (PKA) signaling. Mice deficient in galectin-12 exhibit enhanced adipocyte lipolysis, ...
متن کاملHistogenesis of Sebaceous Gland Carcinomas
Tumors produced by 2-acetylaminofluorene occur with differing frequencies in various organs. The squamous-cell carcinomas of the auditory canal region, reported in the original experiment of Wilson, De Eds, and Cox (23), appear to be of particular interest. There has been considerable discussion in the literature as to their site of origin and mode of development. In our experiment this type of...
متن کاملBurn control, an adipocyte-specific function for galectin-12.
F amilies of molecules often have similar functions—think of kinases, transcription factors, chemokines, or Toll-like receptors. The galectins, an evolutionarily ancient family of carbohydrate binding proteins found in organisms from multicellular fungi to humans, are different (1, 2). Galectins are a family of lectins; the family designation is based on highly conserved structural features, pa...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2016
ISSN: 0022-202X
DOI: 10.1016/j.jid.2016.02.732